Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate
نویسندگان
چکیده
منابع مشابه
Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark; 2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 3Department of Clinical Medicine, MR Research Centre, Aarhus University Hospital, Aarhus, Denmark; 4Neurobiology Research Unit, Rig...
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In this study we set up and optimized a dynamic nuclear polarization (DNP) procedure for the hyperpolarization of a large dose suitable for cardiac metabolic imaging in vivo in swine models. The dose range proposed in this study allowed chemical shift imaging of cardiac metabolism with hyperpolarized [1-C]pyruvate in pigs. We investigated the typical pattern of distribution of [1-C]pyruvate and...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2010
ISSN: 0740-3194
DOI: 10.1002/mrm.22364